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KMID : 0370219730170020103
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Yakhak Hoeji
1973 Volume.17 No. 2 p.103 ~ p.110
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Effect of Atractylis on the Blood Pressuer of the Rabbit
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고석태/Ko ST
문영희/김성오/Moon YH/Kim SO
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Abstract
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In this study the effect of alcohol extract of atractylis (AAE) on the blood pressure of the rabbit was investigated. The results of the experiment are as follows. AAE elicited hypotension with doses ranging from 3 to 30mg/kg, i.v., exhibiting a linear dose-relationship. This effect of AAE was abolished by atropine and potentiated by physostigmine, while not affected by diphenhydramine, hexamethonium, propranolol and cyproheptadine. AAE did not influence the pressor responses to norepinephrine and the depressor to isoproterenol. The above results indicate that AAE produces the hypotension by stimulating the parasympathetic nervous system related to acetylcholine.
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